Post-Fast Refeeding Drives Stem Cell Regeneration via Polyamine Metabolism

Major Finding: Post-fast refeeding contributes to Lgr5⁺ intestinal stem cell proliferation and tumor formation.

Concept: An mTORC1–polyamine–protein synthesis axis drives refeeding-associated regenerative phenotypes.

Impact: These results suggest that fast-refeeding cycles should be carefully executed to avoid tumorigenicity.