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The Fanconi Anemia Pathway Mediates Chromothripsis and Resistance to Cancer Therapy
September 10, 2024
Major Finding: Fanconi anemia pathway activity drives genome rearrangements and ecDNA formation via chromothripsis.
Concept: Recruitment of the SLX4–XPF–ERCC1 endonuclease complex by FANCI–FANCD2 induces chromosome shattering.
Impact: Fanconi anemia-induced genomic rearrangements and ecDNA confer resistance to anti-cancer therapy.
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