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X Chromosome Translocations Drive Sex Bias in a Rare Kidney Cancer Subtype
September 5, 2024
Major Finding: TFE3 fusion events in renal cell carcinoma can involve inactive X chromosomes and drive sex bias.
Concept: Inactive X chromosome translocations can partially reverse X inactivation and cause autosomal silencing.
Impact: Rearrangements of inactivated X chromosomes may explain the female sex bias across various cancer types.
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