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SMYD5 Regulates Translation of Oncogenic Transcripts in Gastric Cancer
August 12, 2024
Major Finding: SMYD5 alters global gene expression patterns to promote gastric adenocarcinoma.
Concept: SMYD5 trimethylates lysine 22 of ribosomal protein rpL40 to enhance translation of oncogenic transcripts.
Impact: Combination approaches including targeting of SMYD5 may be effective in gastric cancer.
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