A Pan-Cancer Single-Cell Atlas of Tumor-Infiltrating B Cells Identifies Phenotypically Distinct Subtypes

Major Finding: Tumor-infiltrating B cells exhibit heterogeneity in abundance and subtype constitution across cancers.

Concept: Tumor-associated atypical B cells interact with CD4⁺ T cells and are activated and clonally expanded.

Impact: Levels of tumor-associated atypical B cells may have prognostic significance across multiple cancers.