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A Perilymphatic Treg–mregDC Niche Blocks Antitumor Immunity
July 30, 2024
Major Finding: Formation of a Treg–mregDC–lymphatic niche prevents tumor antigen trafficking and antitumor immunity.
Concept: Immuno-organization in the TME determines cell states and consequent functionality.
Impact: Disrupting the Treg–mregDC interaction may be a novel therapeutic strategy for various cancers.
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