PFA Ependymomas Exhibit Distinct 3D Genomic Architectures

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July 29, 2024

Major Finding: Posterior fossa group A (PFA) ependymomas have heterochromatic DNA that interacts over long ranges.

Concept: Type B ultra long-range interactions in PFAs (TULIP) were specific to and necessary for tumor cells.

Impact: All PFA ependymomas bore this epigenomic signature, providing a path for therapeutic exploration.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-097

Publisher:American Association for Cancer Research

Article Type: Research Watch

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PFA Ependymomas Exhibit Distinct 3D Genomic Architectures Available to Purchase