Frameshift Switching in Mismatch Repair Genes Facilitates Immune Escape

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July 23, 2024

Major Finding: Stochastic changes in MMR gene homopolymer length balance mutation rate with subclonal diversity.

Concept: Reversible frameshift switching in MMR genes regulates neoantigen diversity and immune recognition.

Impact: Identifying the mechanisms of immune escape in MMRd tumors may help predict response to immunotherapies.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-095

Publisher:American Association for Cancer Research

Article Type: Research Watch

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Frameshift Switching in Mismatch Repair Genes Facilitates Immune Escape Available to Purchase