Pancreatitis Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade

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July 17, 2024

Major Finding: Pancreatitis influences the composition of the immune microenvironment in pancreatic ductal adenocarcinoma (PDAC).

Concept: Pancreatitis recruits type 1 conventional dendritic cells that enable targeting of CD8⁺ T-cell responses against cancer.

Impact: Combining a dendritic cell vaccine with immunotherapy may benefit patients with pancreatitis-associated PDAC.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-093

Publisher:American Association for Cancer Research

Article Type: Research Watch

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Pancreatitis Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Available to Purchase