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PD1+ Macrophages Contribute to Anti-PD1 Efficacy in the Context of Obesity

June 22, 2024

Major Finding: Enhanced PD1 signaling in tumor-associated macrophages hinders antitumor immunity in models of obesity.
Concept: Obesity-associated signaling pathways upregulate macrophage PD1 expression and inhibit macrophage function.
Impact: This study reveals the importance of therapeutically targeting obesity-induced PD1+ macrophages in cancer.

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