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Tumors Rely on Both De Novo and Salvage Pathways of Purine Synthesis

June 24, 2024

Major Finding: Both de novo synthesis and salvage pathways contribute to tumor purine pools and support tumor growth.
Approach: Isotope tracing of de novo synthesis and salvage precursors enables analysis of purine metabolism in vivo.
Impact: This study suggests inhibition of purine salvage as a possible strategy to target tumor metabolism.

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