Tumors Rely on Both De Novo and Salvage Pathways of Purine Synthesis Available to Purchase

Major Finding: Both de novo synthesis and salvage pathways contribute to tumor purine pools and support tumor growth.
Approach: Isotope tracing of de novo synthesis and salvage precursors enables analysis of purine metabolism in vivo.
Impact: This study suggests inhibition of purine salvage as a possible strategy to target tumor metabolism.