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Olfactory Neuroblastoma and Small-Cell Lung Cancer Share Molecular Features

June 14, 2024

Major Finding: A mouse model of olfactory neuroblastoma resembles human disease and mimics small-cell lung cancer.

Concept: ASCL1 expression in olfactory neuroblastoma restricts lineage plasticity and non-neuronal fates.

Impact: Olfactory neuroblastoma may recapitulate small-cell lung cancer subtypes and therapeutic vulnerabilities.

 

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