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Circadian Regulation of T-Cell Infiltration Impacts Antitumor Activity of Immunotherapy

May 29, 2024

Major Finding: Circadian gene expression patterns mediate immune cell infiltration and function within tumors.

Concept: Oscillations in endothelial cell ICAM-1 levels and CD8+ T-cell activity regulate antitumor immunity.

Impact: Optimally timing the first treatment may improve patient responses to immune checkpoint blockade or CAR-T therapy.

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