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Noncanonical PI3Kγ Signaling is a Dependency in a Subset of Acute Leukemias

May 28, 2024

Major Finding: A CRISPR interference screen reveals PI3Kγ signaling as a selective dependency of a high-risk subset of acute leukemias.

Concept: Innate inflammatory signaling induces a noncanonical PI3Kγ–PAK1 signaling axis in acute leukemia.

Impact: The PU3Kγ–PAK1 signaling cascade could be therapeutically targeted in PIK3R5-activated leukemias.

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