GoT-ChA Links Oncogenic Mutations with Chromatin Accessibility Patterns

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May 22, 2024

Major Finding: GoT-ChA enables the simultaneous single-cell capture of genotype and epigenetic profile in human tumors.

Concept: Cell-intrinsic patterns of chromatin accessibility can be parsed out within heterogeneous samples.

Impact: GoT-ChA facilitates the study of mutation-driven epigenetic reprogramming in primary human samples.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-074

Article Type: Research Watch

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