An Extrafollicular B-Cell Maturation Pathway Dampens Antitumor Immunity

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May 15, 2024

Major Finding: Atypical memory (AtM) B cells reside within the tumor microenvironment and suppress antitumor immunity.

Concept: A single-cell, B-cell atlas reveals a noncanonical pathway of B-cell maturation that impacts prognosis.

Impact: This study highlights mechanisms that inform the development of B-cell–targeted immunotherapies.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-071

Article Type: Research Watch

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