Skip to Main Content
Skip Nav Destination

IGSF8 on Cancer Cells Suppresses NK Cell–Mediated Cytotoxicity

May 14, 2024

Major Finding: IGSF8 is highly expressed on cancer cells and inhibits human NK cell function by binding to KIR3LD2.

Concept: An antibody developed to block the IGSF8−KIR3LD2 interaction shows antitumor effects alone or with anti-PD1.

Impact: These results suggest that IGSF8 could be exploited as a potential immunotherapeutic target in cancer.

You do not currently have access to this content.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal