IGSF8 on Cancer Cells Suppresses NK Cell–Mediated Cytotoxicity

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May 14, 2024

Major Finding: IGSF8 is highly expressed on cancer cells and inhibits human NK cell function by binding to KIR3LD2.

Concept: An antibody developed to block the IGSF8−KIR3LD2 interaction shows antitumor effects alone or with anti-PD1.

Impact: These results suggest that IGSF8 could be exploited as a potential immunotherapeutic target in cancer.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-070

Article Type: Research Watch

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IGSF8 on Cancer Cells Suppresses NK Cell–Mediated Cytotoxicity Available to Purchase