DAP5, ICAM1, and CTBP1 Inhibit the Fitness of CD8⁺ Effector T Cells Available to Purchase

Major Finding: Dap5, Icam1, and Ctbp1 were demonstrated to contribute to traits that limit T-cell antitumor activity.

Concept: CRISPR–Cas9 knockout screens were used to identify genes that contribute to T-cell fitness upon differential stimulation.

Impact: This study highlights regulators of T-cell fitness that could be targeted to enhance immunotherapy.