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Chemotherapy Influences Clonal Evolution in Small Cell Lung Cancer

March 21, 2024

Major Finding: Clonal dynamics underlie the initial sensitivity and eventual relapse of small cell lung cancer (SCLC) in response to therapy.

Concept: Spatial and temporal analyses of tumors were used to construct phylogenies and reveal SCLC clonal evolution.

Impact: This study suggests the importance of prioritizing therapies that target the initial founding clone.

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