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The Gut Bacteria Metabolite IPA Enhances Immune Checkpoint Blockade Efficacy

March 26, 2024

Major Finding: Gut bacteria collaborate to produce the metabolite IPA, which modulates the T-cell stemness program.

Concept: IPA enhances H3K27 acetylation at the TCF7 super enhancer to facilitate progenitor exhausted CD8+ T-cell generation.

Impact: Therapeutically enhancing IPA production could improve immunotherapy response in multiple cancers.

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