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Temporal T-Cell Tracking Suggests Effective Combination Therapies

March 14, 2024

Major Finding: Anti–PD-1 immunotherapy increases T-cell differentiation and induces precursor cells through cDC1s.

Concept: A framework was developed to temporally track CD8+ T cells in vivo at single-cell resolution.

Impact: These data suggest that the combination of anti–PD-1 and an anti–4-1BB agonist may increase immunotherapy efficacy.

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