Temporal T-Cell Tracking Suggests Effective Combination Therapies Available to Purchase

Major Finding: Anti–PD-1 immunotherapy increases T-cell differentiation and induces precursor cells through cDC1s.

Concept: A framework was developed to temporally track CD8⁺ T cells in vivo at single-cell resolution.

Impact: These data suggest that the combination of anti–PD-1 and an anti–4-1BB agonist may increase immunotherapy efficacy.