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BAF Complex Mutations Drive B-Cell Germinal Center Re-entry and Lymphomagenesis

March 14, 2024

Major Finding: ARID1A and SMARCA4 mutations promote lymphomagenesis via aberrant re-entry of B cells into germinal centers.

Concept: Re-entry of B cells into germinal centers leads to proliferative bursts and somatic hypermutation.

Impact: These results provide mechanistic insight into how BAF complex mutations can promote lymphomagenesis.

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