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Intramolecular Bivalent Glues Enable Potent and Selective Protein Degradation

March 8, 2024

Major Finding: Intramolecular bivalent glues simultaneously engage two separate sites in cis on a target protein to induce degradation.

Concept: A conformational change is induced upon cis protein domain bridging that enhances surface complementarity with E3 ligases.

Impact: These results suggest that this modality could be a potential strategy to improve targeted protein degradation.

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