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SOX17 Mediates Immune Evasion During Early Colon Cancer Progression

March 8, 2024

Major Finding: Early stage colorectal adenomas and cancers upregulate SOX17 to escape immune surveillance.

Concept: SOX17 suppresses sensitivity to IFNγ signaling and inhibits immunogenicity and antigen presentation.

Impact: These data suggest that restoring IFNγ responses may strengthen immune-mediated tumor clearance.

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