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PDGFRα+ITGA11+ CAFs Promote Early Stage Metastasis of Bladder Cancer

March 8, 2024

Major Finding: PDGFRα+ITGA11+ cancer-associated fibroblasts (CAF) facilitate early stage bladder cancer lymph node metastasis.

Concept: PDGFRα+ITGA11+ CAFs drive lymphangiogenesis and align ECM to promote intravasation and metastasis.

Impact: Therapeutic targeting of PDGFRα+ITGA11+ CAFs could prevent early stage metastasis of bladder cancer.

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