Retinoids Induce Senescence and NK Cell Activity in Prostate Cancer

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March 8, 2024

Major Finding: Retinoids reprogram the senescence response in prostate cancer cells and stimulate NK cell activity.

Concept: Retinoids reverse the pro-tumorigenic effects of the docetaxel-driven SASP through AP-1 inhibition.

Impact: Combining senescence-inducing drugs with NK cell therapy may aid in the treatment of prostate cancer.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-037

Article Type: Research Watch

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Retinoids Induce Senescence and NK Cell Activity in Prostate Cancer Available to Purchase