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HLA-II Locus Heterozygosity Is Associated with Reduced Lung Cancer Risk

February 29, 2024

Major Finding: HLA-II heterozygosity is associated with reduced lung cancer risk in current and former smokers.

Concept: HLA-II heterozygosity promotes immune control of early cancer evolution through smoking-related neoantigen presentation.

Impact: These data suggest that genetic variation in immunosurveillance can contribute to cancer susceptibility.

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