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Tumor Cell Copy Number Alterations Exhibit Tissue Specificity
February 29, 2024
Major Finding: Intrinsic tissue specificity underlies patterns of copy number alterations observed in cancer.
Approach: A forward genetic screen was used to assess the impact of different aneuploidy events on cellular fitness.
Impact: Pro-tumorigenic mechanisms are associated with tumor-specific chromosome-scale copy number alterations.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-034
Article Type:
Research Watch
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