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Chromatin Loop Extrusion Regulates Neutrophil Differentiation

February 22, 2024

Major Finding: Chromatin loop extrusion controls the nuclear morphology and differentiation of neutrophils.

Concept: Neutrophils adopt polymorphonuclear shapes to enable movement through constricted interstitial spaces.

Impact: Engineering nuclear shapes could promote effector immune cell migration into densely populated tumor environments.

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