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Macrophage Efferocytosis Drives Liver Metastasis of Pancreatic Cancer

February 22, 2024

Major Finding: Macrophage-mediated efferocytosis drives macrophage reprogramming and liver metastasis in pancreatic cancer.

Concept: Progranulin expression controls lysosomal acidification and cargo degradation to promote efferocytosis.

Impact: Blockade of efferocytosis represents a potential avenue to treat liver metastasis in pancreatic cancer.

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