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Distinct DNA Replication Machinery Preserves Centromere Integrity

February 22, 2024

Major Finding: Unique DNA replication mechanisms at centromeres help prevent genomic instability and aneuploidy.

Concept: Translesion synthesis enables tolerance of centromeric DNA damage to prevent centromere breakage.

Impact: Drugs that exploit centromere fragility have therapeutic potential in precancerous lesions or tumors.

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