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ID3 Expression Induces Potent Antitumor Immune Activity in Macrophages
February 15, 2024
Major Finding: ID3 promotes Kupffer cell phagocytosis of tumor cells and immune effector cell recruitment.
Concept: ID3-mediated inhibition of ELF1 and E2A binding to SIRPA augments the antitumor immune response.
Impact: ID3 expression in macrophages is sufficient to promote an anticancer niche, which could be harnessed as a potential therapy.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-027
Article Type:
Research Watch
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