Cell-Intrinsic DNA Methylation Regulates Metastatic Tumor Cell Fate

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February 15, 2024

Major Finding: Cell-intrinsic factors determine whether metastatic tumor cells will proliferate or become latent.

Concept: Pre-existing DNA methylation patterns govern the response to Wnt ligands in the lung endothelium.

Impact: Monitoring the epigenetic state of tumor cells in circulation could help predict future metastases.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-026

Article Type: Research Watch

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Cell-Intrinsic DNA Methylation Regulates Metastatic Tumor Cell Fate Available to Purchase