7-Dehydrocholesterol Suppresses Ferroptosis and Phospholipid Peroxidation

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February 8, 2024

Major Finding: 7-Dehydrocholesterol (7-DHC) accumulation prevents phospholipid autoxidation and suppresses ferroptosis.

Concept: Pharmacologic inhibition of 7-DHC biosynthesis promotes ferroptosis and inhibits tumor growth.

Impact: These results suggest that pharmacologic manipulation of 7-DHC levels can be an effective antitumor strategy.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-024

Article Type: Research Watch

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