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SMARCAL1 Favors Tumor Immune Evasion Through Dual Mechanisms

February 8, 2024

Major Finding: SMARCAL1 drives tumor immune escape by suppressing innate immune signaling and inducing PD-L1 expression.

Concept: SMARCAL1 represses activation of the cGAS-STING pathway and cooperates with JUN to enhance PD-L1 expression.

Impact: These results suggest that SMARCAL1 could be a promising cancer immunotherapy target.

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