High Matrix Viscoelasticity Promotes Cell Transformation in the Liver

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February 8, 2024

Major Finding: Advanced glycation end-product (AGE) accumulation in the liver increases matrix viscoelasticity.

Concept: High viscoelasticity activates integrin β1 and YAP/TAZ signaling to promote hepatocellular carcinoma.

Impact: These results suggest that targeting AGEs may be a viable treatment strategy for liver cancer.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-021

Article Type: Research Watch

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