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An Erbin-Mitochondria Axis in Platelets/Megakaryocytes Drives Antitumor Immunity

February 1, 2024

Major Finding: Depletion of Erbin within platelets/megakaryocytes enhances B cell–mediated antitumor immunity.

Concept: Mitochondrial crosstalk between platelets and B cells leads to PD1 degradation and enhanced T cell responses.

Impact: Targeting Erbin therapeutically in platelets/megakaryocytes could reduce colorectal cancer metastasis.

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