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Vascular Cell Interrogation in Brain Metastasis Reveals Immune Regulatory Targets

January 25, 2024

Major Finding: The immune checkpoint molecule CD276 was identified as upregulated in brain metastasis vasculature.

Concept: Single-cell and bulk RNA-sequencing was conducted on brain metastasis and healthy vascular cells.

Impact: These results can be used to design vascular-targeted therapeutic strategies for brain metastases.

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