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Hyperglycosylation of Dendritic Cell Prosaposin Mediates Immune Escape

January 25, 2024

Major Finding: Prosaposin in dendritic cells drives CD8+ T cell–mediated tumor immunity, and its hyperglycosylation mediates immune escape.

Concept: TGF-β induces hyperglycosylation and secretion of prosaposin, hindering antigen cross-presentation.

Impact: Prosaposin-based therapy may enhance antitumor immunity and the efficacy of immune checkpoint blockade.

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