Tumors Reprogram Neutrophils to Promote Angiogenesis and Survival

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January 25, 2024

Major Finding: Upon tumor entry, neutrophils are reprogrammed to increase tumor vascularization and survival.

Concept: Neutrophils of the T3 state migrate to necrotic tumor regions to promote glycolysis, angiogenesis, and survival.

Impact: Targeting deterministic neutrophil reprogramming within tumors may increase the efficacy of immunotherapies.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-012

Article Type: Research Watch

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