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MRE11 Mediates cGAS–STING Activation Upon Oncogene-Induced DNA Damage

January 18, 2024

Major Finding: MRE11 hinders tumorigenesis by promoting cGAS-STING–mediated sensing of cytosolic double-strand DNA.

Concept: MRE11 releases cGAS from nucleosome sequestration and supports DNA damage–induced necroptosis.

Impact: This study delineates an innate immune response to DNA damage that influences tumor suppression.

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