Stromal Density Regulates Stemness and Cancer Risk in Mammary Tissue

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January 18, 2024

Major Finding: Stromal stiffness increases the abundance of mammary epithelial progenitors and raises cancer risk.

Concept: Progesterone-induced RANK signaling and integrin mechanosensing drive basal progenitor expansion.

Impact: Targeting RANK may prevent tumor development or progression in patients with dense breast tissue.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-008

Article Type: Research Watch

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