A Subset of Myofibroblasts Promote Metastasis of Pancreatic Cancer

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January 11, 2024

Major Finding: A subset of cancer-associated myofibroblasts in pancreatic cancer are pro-metastatic and are activated by EGFR.

Concept: Autocrine TGF-β–mediated EGFR activation induces a subset of pro-metastatic myofibroblasts in PDAC.

Impact: Inhibition of EGFR signaling cascades depletes myofibroblasts and has therapeutic promise in PDAC.

DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-004

Article Type: Research Watch

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A Subset of Myofibroblasts Promote Metastasis of Pancreatic Cancer Available to Purchase