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Targeting DCAF5 Rescues SWI/SNF Function in SMARCB1-Mutant Rhabdoid Tumors

April 11, 2024

Major Finding: In SMARCB1-mutant tumors, DCAF5 degrades partially assembled SWI/SNF complexes, thus inactivating them.  

Concept: Targeting DCAF5 in SMARCB1-deficient cells rescues substantial function of SWI/SNF complexes. 

Impact: This study shows that targeting DCAF could rescue the effects of loss of SMARCB1 and reverse the cancer state.

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