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Emerging Technologies and Data Science

Studies, methods, and large datasets that employ computational biology, high-throughput techniques, imaging, physical sciences, or engineering to investigate cancer biology

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Latest in Emerging Technologies and Data Science
June 30 2022
Assessment of Colorectal Cancer Screening Disparities in U.S. Men and Women Using a Demographically Representative Sample
Sumit K. Shah, Marie-Rachelle Narcisse et al.
Timely receipt of colorectal cancer screening can reduce morbidity and mortality. This is the first known study to adopt Andersen's model of health services use to identify factors associated with colorectal cancer screening among U.S. adults. The data from National Health Interview Survey from 2019 was utilized to ...
June 29 2022
Chemical, molecular, and single cell analysis reveal chondroitin sulfate proteoglycan aberrancy in fibrolamellar carcinoma
Adam B. Francisco, Jine Li et al.
Fibrolamellar carcinoma (FLC) is an aggressive liver cancer with no effective therapeutic options. The extracellular environment of FLC tumors is poorly characterized and may contribute to cancer growth and/or metastasis. To bridge this knowledge gap, we assessed pathways relevant to proteoglycans, a major component of ...
June 29 2022
Identification of Drug–Cancer Associations: A Nationwide Screening Study
Kasper Bruun Kristensen, Søren Friis et al.
The main tool in drug safety monitoring, spontaneous reporting of adverse effects, is unlikely to detect delayed adverse drug effects including cancer. Hypothesis-free screening studies based on administrative data could improve ongoing drug safety monitoring. Using Danish health registries, we conducted a series of ...
June 27 2022
Evaluation of the DLL3-targeting antibody-drug conjugate rovalpituzumab tesirine in preclinical models of neuroblastoma
Kateryna Krytska, Colleen E Casey et al.
June 24 2022
Avian paramyxovirus 4 (APMV-4) antitumor activity leads to complete remissions and long-term protective memory in preclinical melanoma and colon carcinoma models
Aryana Javaheri, Yonina Bykov et al.
Avulaviruses represent a diverse subfamily of non-segmented negative strand RNA viruses infecting avian species worldwide. To date, 22 different serotypes have been identified in a variety of avian hosts, including wild and domestic birds. APMV-1, also known as Newcastle disease virus (NDV), is the only avulavirus that ...
June 21 2022
Real-World Studies Link Nonsteroidal Anti-inflammatory Drug Use to Improved Overall Lung Cancer Survival
Jason Roszik, J. Jack Lee et al.
Inflammation is a cancer hallmark. Nonsteroidal anti-inflammatory drugs (NSAIDs) improve overall survival (OS) in certain cancers. Real-world studies explored here if NSAIDs improve non-small cell lung cancer (NSCLC) OS. Analyses independently interrogated clinical databases from The University of Texas MD Anderson ...
June 17 2022
Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Victoria Hoskin, Abdi Ghaffari et al.
The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, largely due to the development of resistance. The adaptor protein ezrin has been shown to ...
June 14 2022
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Laxmi Silwal-Pandit, Stina M. Stålberg et al.
Pancreatic cancer remains a disease with unmet clinical needs and inadequate diagnostic, prognostic, and predictive biomarkers. In-depth characterization of the disease proteome is limited. This study thus aims to define and describe protein networks underlying pancreatic cancer and identify protein centric subtypes with ...
June 09 2022
The Tumor Immune Profile of Murine Ovarian Cancer Models: An Essential Tool for Ovarian Cancer Immunotherapy Research
Galaxia M. Rodriguez, Kristianne J.C. Galpin et al.
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer with an imperative need for new treatments. Immunotherapy has had marked success in some cancer types; however, clinical trials studying the efficacy of immune checkpoint inhibitors for the treatment of EOC benefited less than 15% of patients. Given ...
June 01 2022
Development of an Automated Liquid Biopsy Assay for Methylated Markers in Advanced Breast Cancer
Mary Jo Fackler, Suzana Tulac et al.
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automated Liquid Biopsy for Breast Cancer Methylation (LBx-BCM) prototype, a ...
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