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DRUG DISCOVERY TECHNOLOGIES
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Journal Articles

Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody–Drug Conjugate Targeting Fibroblast Activation Protein

Joseph P. Gallant, Hallie M. Hintz, Gihan S. Gunaratne, Matthew T. Breneman, Emma E. Recchia, Jayden L. West, Kendahl L. Ott, Erika Heninger, Abigail E. Jackson, Natalie Y. Luo, Zachary T. Rosenkrans, Reinier Hernandez, Shuang G. Zhao, Joshua M. Lang, Labros Meimetis, David Kosoff, Aaron M. LeBeau
Journal: Cancer Research Communications
Cancer Research Communications (2024) 4 (6): 1481–1494.
https://doi.org/10.1158/2767-9764.CRC-24-0248
Published: 12 June 2024
View article titled, Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody–Drug Conjugate Targeting Fibroblast Activation Protein
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Includes: Supplementary data
Journal Articles

Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation

Pierpaolo Ginefra, Helen Carrasco Hope, Yi-Hsuan Chiang, Sophie Nutten, Stephanie Blum, George Coukos, Nicola Vannini
Journal: Cancer Research Communications
Cancer Research Communications (2024) 4 (5): 1189–1198.
https://doi.org/10.1158/2767-9764.CRC-24-0022
Published: 03 May 2024
View article titled, Urolithin-A Promotes CD8<sup>+</sup> T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation
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Includes: Supplementary data
Journal Articles

DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors

Helena Folly-Kossi, Joshua D. Graves, Lidija A. Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin
Journal: Cancer Research Communications
Cancer Research Communications (2023) 3 (10): 2096–2112.
https://doi.org/10.1158/2767-9764.CRC-23-0166
Published: 16 October 2023
View article titled, DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors
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Includes: Supplementary data
Journal Articles

Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs

Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, John Wright, Joel Morris, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research Communications
Cancer Research Communications (2023) 3 (8): 1648–1661.
https://doi.org/10.1158/2767-9764.CRC-23-0193
Published: 25 August 2023
View article titled, Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs
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Includes: Supplementary data
Journal Articles

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Alina Castell, Qinzi Yan, Karin Fawkner, Wesam Bazzar, Fan Zhang, Malin Wickström, Mohammad Alzrigat, Marcela Franco, Cecilia Krona, Donald P. Cameron, Cecilia Dyberg, Thale Kristin Olsen, Vasiliki Verschut, Linnéa Schmidt, Sheryl Y. Lim, Loay Mahmoud, Per Hydbring, Sören Lehmann, Laura Baranello, Sven Nelander, John Inge Johnsen, Lars-Gunnar Larsson
Journal: Cancer Research Communications
Cancer Research Communications (2022) 2 (3): 182–201.
https://doi.org/10.1158/2767-9764.CRC-21-0019
Published: 31 March 2022
View article titled, MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
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Includes: Supplementary data
Journal Articles

Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity

Talar Tokatlian, Grace E. Asuelime, Martin S. Naradikian, Jee-Young Mock, Mark E. Daris, Aaron D. Martin, Dora Toledo Warshaviak, Alexander Kamb, Agnes E. Hamburger
Journal: Cancer Research Communications
Cancer Research Communications (2022) 2 (1): 58–65.
https://doi.org/10.1158/2767-9764.CRC-21-0165
Published: 28 January 2022
View article titled, Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity
Open the PDF for Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity in another window
Includes: Supplementary data