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Emerging Technologies and Data Science

Studies, methods, and large datasets that employ computational biology, high-throughput techniques, imaging, physical sciences, or engineering to investigate cancer biology

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Latest in Emerging Technologies and Data Science
May 25 2022
Targeting the ezrin adaptor protein sensitizes metastatic breast cancer cells to chemotherapy and reduces neoadjuvant therapy-induced metastasis
Victoria Hoskin, Abdi Ghaffari et al.
The main cause of cancer-associated death is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, largely due to the development of resistance. The adaptor protein ezrin has been shown to ...
May 23 2022
Proteome analysis of pancreatic tumors implicates extracellular matrix in patient outcome
Laxmi Silwal-Pandit, Stina M. Stålberg et al.
Pancreatic cancer remains a disease with unmet clinical needs and inadequate diagnostic, prognostic and predictive biomarkers. In-depth characterization of the disease proteome is limited. This study thus aims to define and describe protein networks underlying pancreatic cancer and identify protein centric subtypes with ...
May 23 2022
The Tumor Immune Profile of Murine Ovarian Cancer Models: An Essential Tool For Ovarian Cancer Immunotherapy Research.
Galaxia M Rodriguez, Kristianne J.C. Galpin et al.
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer with an imperative need for new treatments. Immunotherapy has had marked success in some cancer types; however, clinical trials studying the efficacy of immune checkpoint inhibitors for the treatment of EOC benefited less than 15% of patients. Given ...
May 18 2022
Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Karoline Pudelko, Angela Wieland et al.
The acquisition of cell invasiveness is the key transition from benign melanocyte hyperplasia to aggressive melanoma. Recent work has provided an intriguing new link between the presence of supernumerary centrosomes and increased cell invasion. Moreover, supernumerary centrosomes were shown to drive non–cell-autonomous ...
May 10 2022
Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C–Mutant Cancers
Husain Yar Khan, Misako Nagasaka et al.
The identification of molecules that can bind covalently to KRAS G12C and lock it in an inactive GDP-bound conformation has opened the door to targeting KRAS G12C selectively. These agents have shown promise in preclinical tumor models and clinical trials. FDA has recently granted approval to sotorasib for KRAS ...
May 10 2022
Tumor Purity in Preclinical Mouse Tumor Models
Wubin Qian, Xiaobo Chen et al.
Tumor biology is determined not only by immortal cancer cells but also by the tumor microenvironment consisting of noncancerous cells and extracellular matrix, together they dictate the pathogenesis and response to treatments. Tumor purity is the proportion of cancer cells in a tumor. It is a fundamental property of ...
May 06 2022
Development of an automated liquid biopsy assay for methylated markers in advanced breast cancer
Mary Jo Fackler, Suzana Tulac et al.
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automated Liquid Biopsy for Breast Cancer Methylation (LBx-BCM) prototype, a ...
May 04 2022
Peripheral Blood Monocyte Abundance Predicts Outcomes in Patients with Breast Cancer
Margaret L. Axelrod, Yu Wang et al.
Biomarkers of response are needed in breast cancer to stratify patients to appropriate therapies and avoid unnecessary toxicity. We used peripheral blood gene expression and cell-type abundance to identify biomarkers of response and recurrence in neoadjuvant chemotherapy–treated patients with breast cancer. We identified ...
April 26 2022
A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms
Qiujin Shen, Yahui Feng et al.
Although the concept of “myeloid neoplasm continuum” has long been proposed, few comparative genomics studies directly tested this hypothesis. Here we report a multi-modal data analysis of 730 consecutive newly diagnosed patients with primary myeloid neoplasm, along with 462 lymphoid neoplasm cases serving as the ...
March 31 2022
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Alina Castell, Qinzi Yan et al.
Deregulated expression of MYC family oncogenes occurs frequently in human cancer and is often associated with aggressive disease and poor prognosis. While MYC is a highly warranted target, it has been considered “undruggable,” and no specific anti-MYC drugs are available in the clinic. We recently identified molecules ...
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