Cancer Research Communications Editors' Picks

2025

June

Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2

Allison W. Kurian, et al.

May

Inferring Drug–Gene Relationships in Cancer Using Literature-Augmented Large Language Models

Ying-Ju Lai, et al.

April

Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory

Anders E. Berglund, et al.

March

Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer

Rachel A. Francis, et al.

February

A Cost-Effective Two-Step Approach for Multi-Cancer Early Detection in High-Risk Populations

Shuaipeng Geng, et al.

January

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

Slavica Dimitrieva, et al.

2024

December

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

Maxim Kuznetsov, et al.

November

Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy

Elisabeth Heath, et al.

October

Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation

Anna Rutkowska, et al.

September

Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium

Paul C. Lott, et al.

August

The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors

Hannah Heath, et al.

July

Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody–Drug Conjugate Targeting Fibroblast Activation Protein

Joseph P. Gallant, et al.

June

Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition

Forrest L. Baker, et al.

May

Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent “NoGlow” Mice

Timothy N. Trotter, et al.

April

A Pilot Study on Patient-specific Computational Forecasting of Prostate Cancer Growth during Active Surveillance Using an Imaging-informed Biomechanistic Model

Guillermo Lorenzo, et al.

March

Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

Jonathan Goldberg, et al.

February

The Oncolytic Activity of Zika Viral Therapy in Human Neuroblastoma In Vivo Models Confers a Major Survival Advantage in a CD24-dependent Manner

Joseph Mazar, et al.

January

Sustained Disease Control in Immune Checkpoint Blockade Responders with Microsatellite Instability-high Colorectal Cancer after Treatment Termination

Kristen Simmons, et al.

2023

December

Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

Felicia Gomez, et al.

November

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

Alexander Semaan, et al.

October

A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

M. Dorso, et al.

September

Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics

Jacqueline L.E. Tearle, et al.

August

The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition

David C. Stieg, et al.

July

Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics

Michal Kazmierski, et al.

June

Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome

Vallijah Subasri, et al.

May

IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

Zoë Johnson, et al.

April

Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men

Jason Garcia, et al.

March

Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer

Channing J. Paller, et al.

February

Incorporating RNA-based Risk Scores for Genomic Instability to Predict Breast Cancer Recurrence and Immunogenicity in a Diverse Population

Alina M. Hamilton, et al.

January

Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient

Tamsin J. Robb, et al.

2022

December

A Preclinical and Phase Ib Study of Palbociclib plus Nab-Paclitaxel in Patients with Metastatic Adenocarcinoma of the Pancreas

Manuel Hidalgo, et al.

Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis

Laura E. Kane, et al.

November

NetrinG1⁺ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress

Kristopher S. Raghavan, et al.

October

Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry

Jason A. White, et al.

September

Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access

Marcus A. Florez, et al.

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Yitian Xu, et al.

August

Tumor Purity in Preclinical Mouse Tumor Models

Wubin Qian, et al.

July

Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors

Ana M. Metelo, et al.

June

Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma

Stephen W. Clark, et al.

May

Race-associated Molecular Changes in Gynecologic Malignancies

Anil K. Sood, et al.