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Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Kazuto Suda; Atsushi Okabe; Junichi Matsuo; Linda Shyue Huey Chuang; Ying Li; Nawaphat Jangphattananont; Naing Naing Mon; Khine Nyein Myint; Akihiro Yamamura; Jimmy Bok-Yan So; Dominic Chih-Cheng Voon; Henry Yang; Khay Guan Yeoh; Atsushi Kaneda; Yoshiaki Ito
A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset
Cankun Wang; Anjun Ma; Yingjie Li; Megan E. McNutt; Shiqi Zhang; Jiangjiang Zhu; Rebecca Hoyd; Caroline E. Wheeler; Lary A. Robinson; Carlos H.F. Chan; Yousef Zakharia; Rebecca D. Dodd; Cornelia M. Ulrich; Sheetal Hardikar; Michelle L. Churchman; Ahmad A. Tarhini; Eric A. Singer; Alexandra P. Ikeguchi; Martin D. McCarter; Nicholas Denko; Gabriel Tinoco; Marium Husain; Ning Jin; Afaf E.G. Osman; Islam Eljilany; Aik Choon Tan; Samuel S. Coleman; Louis Denko; Gregory Riedlinger; Bryan P. Schneider; Daniel Spakowicz; Qin Ma; the exORIEN Consortium
FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Daiki Kanaoka; Mitsuo Yamada; Hironori Yokoyama; Satoko Nishino; Naoshi Kunimura; Hiroshi Satoyoshi; Shota Wakabayashi; Kazunori Urabe; Takafumi Ishii; Masato Nakanishi
Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy
Ignacio Campillo-Marcos; Marta Casado-Pelaez; Veronica Davalos; Gerardo Ferrer; Caterina Mata; Elisabetta Mereu; Gael Roué; David Valcárcel; Antonieta Molero; Lurdes Zamora; Blanca Xicoy; Laura Palomo; Pamela Acha; Ana Manzanares; Magnus Tobiasson; Eva Hellström-Lindberg; Francesc Solé; Manel Esteller
Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies
Vivek Subbiah; Niamh Coleman; Sarina A. Piha-Paul; Apostolia M. Tsimberidou; Filip Janku; Jordi Rodon; Shubham Pant; Ecaterina E. Ileana Dumbrava; Siqing Fu; David S. Hong; Shizhen Zhang; Ming Sun; Yunfang Jiang; Jason Roszik; Juhee Song; Ying Yuan; Funda Meric-Bernstam; Aung Naing
EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
Tanner J. DuCote; Xiulong Song; Kassandra J. Naughton; Fan Chen; Daniel R. Plaugher; Avery R. Childress; Abigail R. Gellert; Erika M. Skaggs; Xufeng Qu; Jinze Liu; Jinpeng Liu; Fei Li; Kwok-Kin Wong; Christine F. Brainson
Natural History of Germline BRCA1 Mutated and BRCA Wild-type Triple-negative Breast Cancer
Nilesh Gardi; Rohan Chaubal; Pallavi Parab; Sunil Pachakar; Suyash Kulkarni; Tanuja Shet; Shalaka Joshi; Yogesh Kembhavi; Pratik Chandrani; Jelmar Quist; Pradnya Kowtal; Anita Grigoriadis; Rajiv Sarin; Raman Govindarajan; Sudeep Gupta
Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation
Jonelle K. Lee; Aditi Chatterjee; Mario Scarpa; Christopher M. Bailey; Sandrine Niyongere; Prerna Singh; Moaath K. Mustafa Ali; Shivani Kapoor; Yin Wang; Giovannino Silvestri; Maria R. Baer
Genomic Characterization and Clinical Outcomes of Patients with Peritoneal Metastases from the AACR GENIE Biopharma Collaborative Colorectal Cancer Registry
Enrique Sanz-Garcia; Samantha Brown; Jessica A. Lavery; Jessica Weiss; Hannah E. Fuchs; Ashley Newcomb; Asha Postle; Jeremy L. Warner; Michele L. LeNoue-Newton; Shawn M. Sweeney; Shirin Pillai; Celeste Yu; Chelsea Nichols; Brooke Mastrogiacomo; Ritika Kundra; Nikolaus Schultz; Kenneth L. Kehl; Gregory J. Riely; Deborah Schrag; Anand Govindarajan; Katherine S. Panageas; Philippe L. Bedard
Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer
Jonathan Goldberg; Na Qiao; Jennifer L. Guerriero; Brett Gross; Yagiz Meneksedag; Yoshimi F. Lu; Anne V. Philips; Tasnim Rahman; Funda Meric-Bernstam; Jason Roszik; Ken Chen; Rinath Jeselsohn; Sara M. Tolaney; George E. Peoples; Gheath Alatrash; Elizabeth A. Mittendorf
Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Henry Chan; Christina V. Trout; David Mikolon; Preston Adams; Roberto Guzman; Konstantinos Mavrommatis; Mahan Abbasian; Haralambos Hadjivassiliou; Lawrence Dearth; Brian A. Fox; Pallavur Sivakumar; Ho Cho; Kandasamy Hariharan
Low-dose Paclitaxel with Pembrolizumab Enhances Clinical and Immunologic Responses in Platinum-refractory Urothelial Carcinoma
Rhonda L. Bitting; Janet A. Tooze; Michael Goodman; Donald C. Vile; Jessica M. Brown; Christopher Y. Thomas; Morgan Neve; Mitra Kooshki; Safoa Addo; Pierre L. Triozzi; Purnima Dubey
Cancer-associated Fibroblast–specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis
James Hutchenreuther; John Nguyen; Katherine Quesnel; Krista M. Vincent; Louis Petitjean; Sophia Bourgeois; Mark Boyd; George Bou-Gharios; Lynne-Marie Postovit; Andrew Leask
INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression
Tsima Abou Kors; Linda Hofmann; Annika Betzler; Kathrina Payer; Martin Bens; Jens Truong; Adrian von Witzleben; Jaya Thomas; Johann M. Kraus; Randa Kalaajieh; Diana Huber; Jasmin Ezić; Julian Benckendorff; Jens Greve; Patrick J. Schuler; Christian H. Ottensmeier; Hans A. Kestler; Thomas K. Hoffmann; Marie-Nicole Theodoraki; Cornelia Brunner; Simon Laban
Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils
Rana Fetit; Alistair S. McLaren; Mark White; Megan L. Mills; John Falconer; Xabier Cortes-Lavaud; Kathryn Gilroy; Tamsin R.M. Lannagan; Rachel A. Ridgway; Colin Nixon; Varushka Naiker; Renee Njunge; Cassie J. Clarke; Declan Whyte; Kristina Kirschner; Rene Jackstadt; Jim Norman; Leo M. Carlin; Andrew D. Campbell; Owen J. Sansom; Colin W. Steele
Cumulative Incidence, Risk Factors, and Overall Survival of Disease Recurrence after Curative Resection of Stage II–III Colorectal Cancer: A Population-based Study
Tara C. Boute; Hidde Swartjes; Marjolein J.E. Greuter; Marloes A.G. Elferink; Rik van Eekelen; Geraldine R. Vink; Johannes H.W. de Wilt; Veerle M.H. Coupé
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