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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Shruti Lal; Neil E. Bhola; Bee-Chun Sun; Yuping Chen; Tom Huang; Vivian Morton; Kevin X. Chen; Shanghua Xia; Haoyu Zhang; Nehal S. Parikh; Qiuping Ye; O. Petter Veiby; David I. Bellovin; Yuhua Ji
PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction In Vitro and In Vivo
Lisa Marie Fröhlich; Heike Niessner; Birgit Sauer; Sofie Kämereit; Eftychia Chatziioannou; Simon Riel; Tobias Sinnberg; Birgit Schittek
Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Valerie P. O'Brien; Yuqi Kang; Meera K. Shenoy; Greg Finak; William C. Young; Julien Dubrulle; Lisa Koch; Armando E. Rodriguez Martinez; Jeffery Williams; Elizabeth Donato; Surinder K. Batra; Cecilia C.S. Yeung; William M. Grady; Meghan A. Koch; Raphael Gottardo; Nina R. Salama
Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment
Jiahui Liu; Wenqiang Yan; Huishou Fan; Jingyu Xu; Lingna Li; Chenxing Du; Xuehan Mao; Yuting Yan; Yan Xu; Weiwei Sui; Shuhui Deng; Shuhua Yi; Kenneth C. Anderson; Lugui Qiu; Dehui Zou; Gang An
A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer
M. Dorso; Payal T. Patel; Aleksandr Pankov; Jacob A. Boyer; Rajesh K. Soni; Isabella S. Del Priore; Omar Hayatt; Amanda Kulick; Connor J. Hagen; Elisa de Stanchina; Melissa R. Junttila; Anneleen Daemen; Lori S. Friedman; Ronald C. Hendrickson; Sarat Chandarlapaty
Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy
Richard W. Davis, IV; Astero Klampatsa; Gwendolyn M. Cramer; Michele M. Kim; Joann M. Miller; Min Yuan; Cassandra Houser; Emma Snyder; Mary Putt; Sergei A. Vinogradov; Steven M. Albelda; Keith A. Cengel; Theresa M. Busch
Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer
Kanoko Katoh; Yuki Katoh; Akiko Kubo; Miho Iida; Yuji Ikeda; Takashi Iwata; Hiroshi Nishio; Masaki Sugawara; Daiki Kato; Makoto Suematsu; Shuichi Hirai; Kei Kawana
A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors
Glenn J. Hanna; Anastasios Stathis; Elena Lopez-Miranda; Fabricio Racca; Doris Quon; Serge Leyvraz; Dagmar Hess; Bhumsuk Keam; Jordi Rodon; Myung-Ju Ahn; Hye Ryun Kim; Andreas Schneeweiss; Josep-Maria Ribera; Daniel DeAngelo; Jose Manuel Perez Garcia; Javier Cortes; Oliver Schönborn-Kellenberger; Dirk Weber; Pavel Pisa; Michael Bauer; Laura Beni; Maria Bobadilla; Raj Lehal; Michele Vigolo; Florian D. Vogl; Elena Garralda
EphA2 Proteolytic Fragment as a Sensitive Diagnostic Biomarker for Very Early-stage Pancreatic Ductal Carcinoma
Shinya Sato; Masatoshi Nakagawa; Takeshi Terashima; Soichiro Morinaga; Yohei Miyagi; Eisaku Yoshida; Toru Yoshimura; Motoharu Seiki; Shuichi Kaneko; Makoto Ueno; Taro Yamashita; Naohiko Koshikawa
Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment
Jesus Amo-Aparicio; Adrian Dominguez; Shaikh M. Atif; Alberto Dinarello; Tania Azam; Kibrom M. Alula; Miles Piper; Christopher H. Lieu; Robert W. Lentz; Alexis D. Leal; Stacey M. Bagby; Wells A. Messersmith; Sana D. Karam; Charles A. Dinarello; Todd M. Pitts; Carlo Marchetti
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer
Devra Olson; Janelle Taylor; Kelsi Willis; Kelly Hensley; Sean Allred; Margo Zaval; Lauren Farr; Robert Thurman; Nishi Jain; Renee Hein; Michelle Ulrich; Scott Peterson; Anita Kulukian
An Early Neoplasia Index (ENI10), Based on Molecular Identity of CD10 Cells and Associated Stemness Biomarkers, is a Predictor of Patient Outcome in Many Cancers
Boris Guyot; Flora Clément; Youenn Drouet; Xenia Schmidt; Sylvain Lefort; Emmanuel Delay; Isabelle Treilleux; Jean-Philippe Foy; Sandrine Jeanpierre; Emilie Thomas; Janice Kielbassa; Laurie Tonon; Helen He Zhu; Pierre Saintigny; Wei-Qiang Gao; Arnaud de la Fouchardiere; Franck Tirode; Alain Viari; Jean-Yves Blay; Véronique Maguer-Satta
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